2021-10-19 17:36:00
Leukemia??
is group of disorder characterized by unregulated and accumulation of one cell type in the bone marrow and blood ...
eitology
the exactly cause not known but there are many factor believed play role in disease like ?::?
genetic factor (chromosome abnormalities)
environmental factor like ??
ionized radiation
mutogenic chemical
viral infection
Symptom
The malignant cell cause symptoms because
bone marrow failure
infiltration of organ
defect in maturation and regulations of Wbcs suppress or dysfunctional for immune system unable to fight any simple infection. Because WBCs play major role in immune system
defect in number of platelet bleeding ..brusing ..petechiae
defect in number of RBCs anaemia
Classification of leukemia
Acute leukemia
Acute lymphocytic leukemia ..ALL
B.ALL
T.ALL
Acute myelocytic leukemia ..AML
Chronic leukemia
Chronic lymphocytic leukemia..CLL
Chronic myelocytic leukemia..CML
Incidence
Acute leukemia occur in all age group
ALL ..Common in children
AML...in Adult
Chronic leukemia as usually disease of Adult
CLL rare in children usuall before age 40..
CML peak age 30_50
Diagnosis
morphological..blood film
bone marrow aspirations
cytochemical stain
immunophenotype ...use CD marker
cytogentic analysis and molecular examination
biochemical test
Treatment
Chemotherapy
Radio therapy
bone marrow transplantation
immune therapy
ملحوظه
Some leukemia patients
do not have high white blood cell counts visible during a regular blood count This less-common condition is called Aleukemia The bone marrow still contains cancerous white blood cells which disrupt the normal production of blood cells but they remain in the marrow instead of entering the bloodstream where they would be visible in a blood test. For an aleukemic patient the white blood cell counts in the bloodstream can be normal or low. Aleukemia can occur in any of the four major types of leukemia....
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