#Hematology_18 #Anemia #Macrocytic_anemia_3 Clinical Present | "لعلي أفيدك" Clinical discussion

#Hematology_18 #Anemia #Macrocytic_anemia_3
Clinical Presentation of VitB12 & folate deficiency

General Manifestation of anemia
ال Macrocytic anemia زيها زي اي نوع انيميا هيشتكي المريض من اعراض عامة زي
Fatigue - pallor - weakness - dizziness
وشرحناهم ببوست منفصل
https://t.me/l3lee_afeedk/1598
اللي بيهمنا اكتر هي اعراض نقص B12 وال folate

Specific manifestation of B12 deficiency

Specific manifestation of folate deficiency

نقص B12 بيعمل الاعراض التالية :
GIT manifestation
زي ال glossitis مع وجود pain و swelling و Tenderness
بعض الحالات بتيجي ب Tongue hyperpigmentation
و loss of tongue papilla

Neuropsychiatric change
اكتر حاجه بيشتكي منها المريض ال numbness و symmetric paraesthesias
و neuropathy ( periphral neuritis) خاصة بال Leg
بعض الحالات خاصة لو sever B12 deficiency بيصير
Demyelination of white matter in spinal cord , which lead to ataxia , progressive weakness , paraplegia , spasticity

Skin pigmentation , pallor , Jaundice
increas Risk of Osteoporosis and Hip , spine fracture
CNS : Dementia , Depression , Extrapyramidal signs (eg, dystonia, dysarthria, rigidity)


أما نقص ال folic acid
اشهر الاعراض هتكون glossitis و mouth Ulcer
in fetus, can present as neural tube defect in fetus of mother with folate deficiency

in adults
depression, dementia, optic neuropathy, myelopathy, and peripheral neuropathy have been reported in patients with folate deficiency
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